Chemicals

Chemical   Links Effects Comments
A
anisomycin   Wiki
Tocris
Inhibits protein synthesis.  
2-APB   Cayman
Tocris
Wiki
Inhibits IP3 receptors.
Blocks some gap junctions.
Affects some TRP channels.
 
AP5        
C
caffeine        
CNQX        
ω-conotoxin G VI A CTX-GVIA Tocris Blocks N-type VGCCs. Reversible.
ω-conotoxin M VII C CTX-MVIIC Tocris Blocks N-, P/Q-type VGCCs.  
CPA   Wiki
Tocris
Inhibits SERCA. Cell-permeable, reversible.
cycloheximide   Wiki
Ascent Scientific
Inhibits protein synthesis.  
D
DHPG   Wiki
Ascent Scientific
Activates group I mGluRs.  
H
heparin   EMD Inhibits IP3-activated Ca2+ release from ER.  
K
KN93   Tocris Inhibits CaMKII.
Inhibits L-type calcium channels.
Open channel blocker of some voltage-gated K+ channels
Ref: L-type Ca2+ channels
Ref: Kv1.5
kynurenate        
N
nifedipine    Wiki
Tocris
Blocks L-type Ca2+ channels.  
nimodipine        
R
rapamycin   Wiki Inhibits mTOR.  
ruthenium red        
ryanodine   Wiki Locks the RyRs in a half-open state and eventually depletes the store (<10 µM).
Inhibits RyRs irreversibly (~100 µM).
The binding of ryanodine to RyRs is use-dependent.
S
strychnine   Wiki Blocks inhibitory glycine receptors.  
T
thapsigargin   Wiki Inhibits SERCA.
Raises [Ca2+]in and depletes the calcium store.
Store-depletion can secondarily activate plasma membrane calcium channels.
TTX tetrodotoxin      
X
Xestospongin C   Caymen
Biomol
Sigma
EMD