NEURON Tutorial #19


Goals: Compare Four Models

Specific Aims:


Summary:

Fixed variable (except No Ih): gbar_h = 3e-5 (S/cm2)
e_pas was adjusted so the resting membrane potential is -65 mV.

No Ih Sonia's Model Sonia's Model 2 Payne's (C<->O) model Payne's (C<->O)2 model Altomare's Model Modefied Altomare's Model 1 Modefied Altomare's Model 2 Modefied Altomare's Model 3
Tutorial #   13 13.a 14 16 17 18 18 18
e_pas (mV) -65 -68.8 -68.8 -68.0 -69.0 -78.5 -67.1 -67.1 -66.9
Membrane Time Constant (ms) 30.01 25.10 25.48 25.66 24.04 20.94 28.53 28.27 27.45
Rin (M Ohm) 95.49 63.07 63.07 65.7 58.2 42.8 66.8 66.8 68.42
Rebound Slope (mV/mV) 0.0 -0.12 -0.14 -0.12 -0.12 -0.19 -0.25 -0.22 -0.15
Temporal Summation (%) 43.68 17.16 16.73 20.35 12.52 -4.57 21.43 21.54 24.08
Depolarizing Resonance Frequency (Hz) 0.6 0.6 2.8 0.6 0.7 5.3 2.7 0.6 0.6
Hyperpolarizing Resonance Frequency (Hz) 1.1 3.9 3.8 3.7 4.7 5.7 3.2 3.5 3.6
Vhalf (mV)   -81.0 -81.0 -81.3 -79.4 -68.9 -80.5 -80.4 -80.9
k (mV)   7.8 7.8 7.3 8.3 9.4 6.5 6.5 6.5
      tau = 45 (ms)         delta_0 = 80 gamma_0 = 0.2619

 

No Ih Sonia's Model Sonia's Model 2 Payne's (C<->O) model Payne's (C<->O)2 model Altomare's Model Modefied Altomare's Model 1 Modefied Altomare's Model 2 Modefied Altomare's Model 3
Tutorial #   13 13.a 14 16 17 18 18 18
Impedance Magnitude No Ih Sonia's Ih Model Impedance Magnitude Impedance Magnitude Impedance Magnitude Impedance Magnitude Impedance Magnitude Impedance Magnitude Impedance Magnitude
Voltage Lag No Ih Sonia's Ih - Voltage lag Voltage Lag Voltage Lab Voltage Lag Voltage Lag Voltage Lag Voltage Lag Voltage Lag
Time Constant   Sonia's Ih Model - Time Constant Time Constant Time Constant Time Constant Time Constant Time Constant Time Constant Time Constant
      tau = 45 (ms)         delta_0 = 80 gamma_0 = 0.2619

Fixed variable: gbar_h = 5e-5 (S/cm2)
e_pas is adjusted so the resting membrane potential is -65 mV.

Sonia's Model Payne's (C<->O) model Payne's (C<->O)2 model Altomare's Model Modefied Altomare's Model Modefied Altomare's Model 2
Tutorial # 13 14 16 17 18 18
e_pas (mV) -71.3 -70 -71.7 -87.5 -68.5 -68.5
Membrane Time Constant (ms) 23.5 24.3 22.5 18.1 28.0 27.7
Rin (M Ohm) 51.7 54.9 46.1 31.1 56.5 56.5
Rebound Slope (mV/mV) -0.21 -0.21 -0.22 -0.32 -0.39 -0.35
Temporal Summation (%) 5.60 9.25 0.27 -13.9 9.50 9.76
Depolarizing Resonance Frequency (Hz) 4.3 3.8 5.3 6.9 3.6 3.8
Hyperpolarizing Resonance Frequency (Hz) 5 4.7 6 7.1 3.9 4.1
Vhalf (mV) -81.1 -81.4 -79.7 -69.0 -80.7 -80.5
k (mV) 7.9 7.4 8.5 9.5 6.6 6.6
            delta_0 = 80

Fixed variable: e_pas = -70 (mV)
gbar_h is adjusted so the resting membrane potential is -65 mV.

Sonia's Model Payne's (C<->O) model Payne's (C<->O)2 model Altomare's Model Modefied Altomare's Model Modefied Altomare's Model 2
Tutorial # 13 14 16 17 18 18
gbar_h (S/cm2) 4e-5 5e-5 3.7e-5 1.1e-5 7.2e-5 7.1e-5
Membrane Time Constant (ms) 24.3 24.3 23.4 24.9 27.4 27.1
Rin (M Ohm) 56.9 54.9 53.3 66.0 48.3 48.4
Rebound Slope (mV/mV) -0.17 -0.21 -0.15 -0.05 -0.52 -0.47
Temporal Summation (%) 11.0 9.2 7.5 16.9 -0.98 -0.19
Depolarizing Resonance Frequency (Hz) 3.5 3.8 3.5 2.3 4.2 4.6
Hyperpolarizing Resonance Frequency (Hz) 4.5 4.7 5.2 3.3 4.4 4.7
Vhalf (mV) -81.1 -81.4 -79.7 -69.0 -80.7 -80.5
k (mV) 7.9 7.4 8.5 9.5 6.6 6.6