NEURON Tutorial #11


Goals: Examine activation and deactivation kinetics of Ih.

Specific Aims:

Downloads:


Order Comparison:
s2 shifts the curve to the left.
(1 - s2) shifts the curve to the right.

s (control) s2 1 - s2
gbar_h = 5.3e-5 (S/cm2)
vhalf = -80.5 (mV)
k = 6.7 (mV)
gbar_h = 6.7e-5 (S/cm2)
vhalf = -73.05 (mV)
k = 7.97 (mV)
gbar_h = 4.6e-5 (S/cm2)
vhalf = -87.95 (mV)
k = -7.97 (mV)
Tau = 24.34 (ms)
Rin = 44.51 (MΩ)
Sag = 21.47 (%)
Temporal Summation = 7.31 (%)
Depolarizing Resonance Frequency = 4.2 (Hz)
Hyperpolarizing Resonance Frequency = 4.8 (Hz)
Tau = 24.30 (ms)
Rin = 38.37 (MΩ)
Sag = 28.64 (%)
Temporal Summation = 1.61 (%)
Depolarizing Resonance Frequency = 4.9 (Hz)
Hyperpolarizing Resonance Frequency = 5.4 (Hz)
Tau = 24.41 (ms)
Rin = 48.03 (MΩ)
Sag = 18.35 (%)
Temporal Summation = 10.13 (%)
Depolarizing Resonance Frequency = 3.7 (Hz)
Hyperpolarizing Resonance Frequency = 4.5 (Hz)

Activation Tau

Activation

Deactivation Tau

Deactivation Tau

The results of time constants are not satisfactory.